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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM74445
Substrate
n/a
Meas. Tech.
Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM74445
Synonyms:
2-[2-(4-chloroanilino)-2-keto-ethyl]sulfinyl-N-(isochroman-1-ylmethyl)acetamide | 2-[2-(4-chloroanilino)-2-oxoethyl]sulfinyl-N-(3,4-dihydro-1H-2-benzopyran-1-ylmethyl)acetamide | 2-[2-(4-chloroanilino)-2-oxoethyl]sulfinyl-N-(3,4-dihydro-1H-isochromen-1-ylmethyl)acetamide | 2-[2-[(4-chlorophenyl)amino]-2-oxidanylidene-ethyl]sulfinyl-N-(3,4-dihydro-1H-isochromen-1-ylmethyl)ethanamide | MLS000033071 | N-(4-Chloro-phenyl)-2-{[(isochroman-1-ylmethyl)-carbamoyl]-methanesulfinyl}-acetamide | SMR000006648 | cid_648769
Type:
Small organic molecule
Emp. Form.:
C20H21ClN2O4S
Mol. Mass.:
420.91
SMILES:
Clc1ccc(NC(=O)CS(=O)CC(=O)NCC2OCCc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: