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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM74541
Substrate
n/a
Meas. Tech.
Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM74541
Synonyms:
MLS001157989 | N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-4-oxidanylidene-1-phenyl-pyridazine-3-carboxamide | N-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]-4-oxo-1-phenylpyridazine-3-carboxamide | N-[4-[(3,4-dimethyl-5-isoxazolyl)sulfamoyl]phenyl]-4-oxo-1-phenyl-3-pyridazinecarboxamide | N-[4-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]phenyl]-4-keto-1-phenyl-pyridazine-3-carboxamide | SMR000651400 | cid_16452711
Type:
Small organic molecule
Emp. Form.:
C22H19N5O5S
Mol. Mass.:
465.482
SMILES:
Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3nn(ccc3=O)-c3ccccc3)cc2)c1C
Structure:
Search PDB for entries with ligand similarity: