Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM75357
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2
IC50
59500±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM75357
Synonyms:
MLS-0435607.0001 | [4-amino-3-(5-chloro-2-methoxy-phenyl)-2-thioxo-4-thiazolin-5-yl]-morpholino-methanone | [4-amino-3-(5-chloro-2-methoxyphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-morpholin-4-ylmethanone | [4-amino-3-(5-chloro-2-methoxyphenyl)-2-sulfanylidene-5-thiazolyl]-(4-morpholinyl)methanone | [4-azanyl-3-(5-chloranyl-2-methoxy-phenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-morpholin-4-yl-methanone | cid_42585970
Type:
Small organic molecule
Emp. Form.:
C15H16ClN3O3S2
Mol. Mass.:
385.889
SMILES:
COc1ccc(Cl)cc1-n1c(N)c(sc1=S)C(=O)N1CCOCC1 |(3.08,-3.92,;4.41,-3.15,;5.75,-3.92,;5.75,-5.46,;7.08,-6.23,;8.41,-5.46,;9.75,-6.23,;8.41,-3.92,;7.08,-3.15,;7.08,-1.61,;8.33,-.7,;9.79,-1.18,;7.85,.76,;6.31,.76,;5.84,-.7,;4.37,-1.18,;8.76,2.01,;10.29,1.85,;8.13,3.41,;6.6,3.58,;5.97,4.98,;6.88,6.23,;8.41,6.07,;9.04,4.66,)|
Structure:
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