Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM75404
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75404
Synonyms:
1-[2-furanylmethyl-[oxo(2-pyridinyl)methyl]amino]-1-cyclohexanecarboxylic acid propan-2-yl ester | 1-[2-furfuryl(picolinoyl)amino]cyclohexanecarboxylic acid isopropyl ester | KSC-12-15B | KUC104506N | cid_44665689 | propan-2-yl 1-[furan-2-ylmethyl(pyridin-2-ylcarbonyl)amino]cyclohexane-1-carboxylate | propan-2-yl 1-[furan-2-ylmethyl(pyridine-2-carbonyl)amino]cyclohexane-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C21H26N2O4
Mol. Mass.:
370.4421
SMILES:
CC(C)OC(=O)C1(CCCCC1)N(Cc1ccco1)C(=O)c1ccccn1
Structure:
Search PDB for entries with ligand similarity: