Target
Estrogen receptor
Ligand
BDBM269359
Substrate
n/a
Meas. Tech.
ERalpha Degradation (MCF7 Cells)
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
2.00±n/a nM
Comments
extracted
Citation
 Burks, HEDechantsreiter, MAHe, GNunez, JPeukert, SSpringer, CSun, YThomsen, NMTria, GSYu, B Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders US Patent  US10058534 Publication Date 8/28/2018 
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM269359
Synonyms:
(E)-3-(4-((2-(2,3- dimethylphenyl)-6- hydroxybenzo[b] thiophen-3-yl)oxy) phenyl)-acrylic acid | US10058534, 13
Type:
Small organic molecule
Emp. Form.:
C25H20O4S
Mol. Mass.:
416.489
SMILES:
Cc1cccc(-c2sc3cc(O)ccc3c2Oc2ccc(\C=C\C(O)=O)cc2)c1C
Structure:
Search PDB for entries with ligand similarity: