Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75611
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75611
Synonyms:
2-(2-ethyl-1-piperidinyl)-3-oxo-4H-1,4-benzothiazine-6-carboxylic acid methyl ester | 2-(2-ethylpiperidino)-3-keto-4H-1,4-benzothiazine-6-carboxylic acid methyl ester | MLS000096012 | SMR000031560 | cid_3241622 | methyl 2-(2-ethylpiperidin-1-yl)-3-oxidanylidene-4H-1,4-benzothiazine-6-carboxylate | methyl 2-(2-ethylpiperidin-1-yl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate | methyl 2-(2-ethylpiperidin-1-yl)-3-oxo-4H-1,4-benzothiazine-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H22N2O3S
Mol. Mass.:
334.433
SMILES:
CCC1CCCCN1C1Sc2ccc(cc2NC1=O)C(=O)OC
Structure:
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