Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75665
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
59900±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75665
Synonyms:
MLS001101286 | N-[2-[1-(2-ethoxybenzyl)-4-piperidyl]pyrazol-3-yl]-3-phenyl-propionamide | N-[2-[1-[(2-ethoxyphenyl)methyl]-4-piperidinyl]-3-pyrazolyl]-3-phenylpropanamide | N-[2-[1-[(2-ethoxyphenyl)methyl]piperidin-4-yl]pyrazol-3-yl]-3-phenyl-propanamide | N-[2-[1-[(2-ethoxyphenyl)methyl]piperidin-4-yl]pyrazol-3-yl]-3-phenylpropanamide | SMR000655267 | cid_24791181
Type:
Small organic molecule
Emp. Form.:
C26H32N4O2
Mol. Mass.:
432.5579
SMILES:
CCOc1ccccc1CN1CCC(CC1)n1nccc1NC(=O)CCc1ccccc1
Structure:
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