Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM67418
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM67418
Synonyms:
2-(4-Hydroxy-piperidin-1-yl)-6-methoxy-quinoline-3-carbonitrile | 2-(4-hydroxy-1-piperidinyl)-6-methoxy-3-quinolinecarbonitrile | 2-(4-hydroxypiperidin-1-yl)-6-methoxyquinoline-3-carbonitrile | 2-(4-hydroxypiperidino)-6-methoxy-quinoline-3-carbonitrile | 6-methoxy-2-(4-oxidanylpiperidin-1-yl)quinoline-3-carbonitrile | MLS000074860 | SMR000005596 | cid_650445
Type:
Small organic molecule
Emp. Form.:
C16H17N3O2
Mol. Mass.:
283.3251
SMILES:
COc1ccc2nc(N3CCC(O)CC3)c(cc2c1)C#N
Structure:
Search PDB for entries with ligand similarity: