Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM31074
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
3882±716 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM31074
Synonyms:
MLS000062611 | N-(6-methoxy-8-quinolinyl)-4-methylbenzenesulfonamide | N-(6-methoxy-8-quinolyl)-4-methyl-benzenesulfonamide | N-(6-methoxyquinolin-8-yl)-4-methyl-benzenesulfonamide | N-(6-methoxyquinolin-8-yl)-4-methylbenzenesulfonamide | SMR000071147 | cid_130606
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3S
Mol. Mass.:
328.386
SMILES:
COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1
Structure:
Search PDB for entries with ligand similarity: