Target
Type-1 angiotensin II receptor
Ligand
BDBM67263
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
13714±2407 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM67263
Synonyms:
3-amino-4-(1-pyrrolidinyl)-1-benzopyran-2-one | 3-amino-4-pyrrolidin-1-ylchromen-2-one | 3-amino-4-pyrrolidino-coumarin | 3-azanyl-4-pyrrolidin-1-yl-chromen-2-one | MLS000711271 | SMR000281038 | cid_43001
Type:
Small organic molecule
Emp. Form.:
C13H14N2O2
Mol. Mass.:
230.2625
SMILES:
Nc1c(N2CCCC2)c2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: