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Targetinsulin-degrading enzyme isoform 1 precursor
LigandBDBM75787
Substrate/Competitorn/a
Meas. Tech.Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE)
IC50 2984±n/a nM
Citation PubChem, PC Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
insulin-degrading enzyme isoform 1 precursor
Name:insulin-degrading enzyme isoform 1 precursor
Synonyms:Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin
Type:Enzyme Catalytic Domain
Mol. Mass.:117968.59
Organism:Homo sapiens (Human)
Description:P14735
Residue:1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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  Blast E-value cutoff:
BDBM75787
NameBDBM75787
Synonyms:3-[[4-(2-methyl-2,3-dihydroindole-1-carbonyl)phenyl]methylamino]-4-(4-methylpiperidin-1-yl)cyclobut-3-ene-1,2-dione | 3-[[4-(2-methylindoline-1-carbonyl)benzyl]amino]-4-(4-methylpiperidino)cyclobut-3-ene-1,2-quinone | 3-[[4-[(2-methyl-2,3-dihydroindol-1-yl)-oxomethyl]phenyl]methylamino]-4-(4-methyl-1-piperidinyl)cyclobut-3-ene-1,2-dione | 3-[[4-[(2-methyl-2,3-dihydroindol-1-yl)carbonyl]phenyl]methylamino]-4-(4-methylpiperidin-1-yl)cyclobut-3-ene-1,2-dione | MLS000119688 | SMR000096609 | cid_5309815
TypeSmall organic molecule
Emp. Form.C27H29N3O3
Mol. Mass.443.5375
SMILESCC1Cc2ccccc2N1C(=O)c1ccc(CNc2c(N3CCC(C)CC3)c(=O)c2=O)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a