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Targetinsulin-degrading enzyme isoform 1 precursor
LigandBDBM75792
Substrate/Competitorn/a
Meas. Tech.Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE)
IC50 4000±n/a nM
Citation PubChem, PC Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
insulin-degrading enzyme isoform 1 precursor
Name:insulin-degrading enzyme isoform 1 precursor
Synonyms:Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin
Type:Enzyme Catalytic Domain
Mol. Mass.:117968.59
Organism:Homo sapiens (Human)
Description:P14735
Residue:1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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  Blast E-value cutoff:
BDBM75792
NameBDBM75792
Synonyms:2-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonylphenyl]-4-methyl-3a,4,7,7a-tetrahydroisoindole-1,3-dione | 2-[3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]phenyl]-4-methyl-3a,4,7,7a-tetrahydroisoindole-1,3-dione | 2-[3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]phenyl]-4-methyl-3a,4,7,7a-tetrahydroisoindole-1,3-quinone | 2-[3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]phenyl]-4-methyl-3a,4,7,7a-tetrahydroisoindole-1,3-dione | MLS000520925 | SMR000131334 | cid_4321479
TypeSmall organic molecule
Emp. Form.C28H31N3O3
Mol. Mass.457.564
SMILESCC1C=CCc2c(O)n(c(O)c12)-c1cccc(c1)C(=O)N1CCN(CC1)c1cccc(C)c1C |c:2|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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