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Targetinsulin-degrading enzyme isoform 1 precursor
LigandBDBM50738
Substrate/Competitorn/a
Meas. Tech.Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE)
IC50 570.66±n/a nM
Citation PubChem, PC Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
insulin-degrading enzyme isoform 1 precursor
Name:insulin-degrading enzyme isoform 1 precursor
Synonyms:Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin
Type:Enzyme Catalytic Domain
Mol. Mass.:117968.59
Organism:Homo sapiens (Human)
Description:P14735
Residue:1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQE
LLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQ
LYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAI
VSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPL
EKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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  Blast E-value cutoff:
BDBM50738
NameBDBM50738
Synonyms:MLS000762832 | N-[(2,3-dimethoxyphenyl)methylideneamino]-8-methyl-5H-pyrimido[5,4-b]indol-4-amine | N-[1-(2,3-Dimethoxy-phenyl)-meth-(E)-ylidene]-N'-(8-methyl-5H-pyrimido[5,4-b]indol-4-yl)-hydrazine | SMR000439805 | [(2,3-dimethoxybenzylidene)amino]-(8-methyl-5H-pyrimid[5,4-b]indol-4-yl)amine | cid_4895375
TypeSmall organic molecule
Emp. Form.C20H19N5O2
Mol. Mass.361.3972
SMILESCOc1cccc(CN=Nc2ncnc3c4cc(C)ccc4[nH]c23)c1OC |w:9.9|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a