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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM75909
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
7500±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) PubChem Bioassay (2010)[AID] 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM75909
Synonyms:
5-(4-methoxyphenoxy)-6-oxidanylidene-1-(4-propan-2-ylphenyl)pyridazine-4-carbonitrile | 5-(4-methoxyphenoxy)-6-oxo-1-(4-propan-2-ylphenyl)-4-pyridazinecarbonitrile | 5-(4-methoxyphenoxy)-6-oxo-1-(4-propan-2-ylphenyl)pyridazine-4-carbonitrile | 6-keto-5-(4-methoxyphenoxy)-1-p-cumenyl-pyridazine-4-carbonitrile | SR-02000000431 | SR-02000000431-1 | cid_46835802
Type:
Small organic molecule
Emp. Form.:
C21H19N3O3
Mol. Mass.:
361.3939
SMILES:
COc1ccc(Oc2c(cnn(-c3ccc(cc3)C(C)C)c2=O)C#N)cc1
Structure:
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