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Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM75936
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
3500±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) PubChem Bioassay (2010)[AID] 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM75936
Synonyms:
SR-02000000472 | SR-02000000472-1 | [4-[5-chloranyl-3-oxidanylidene-2-(4-propan-2-ylphenyl)pyridazin-4-yl]oxyphenyl]methyl ethanoate | [4-[5-chloro-3-oxo-2-(4-propan-2-ylphenyl)pyridazin-4-yl]oxyphenyl]methyl acetate | acetic acid [4-(5-chloro-3-keto-2-p-cumenyl-pyridazin-4-yl)oxybenzyl] ester | acetic acid [4-[[5-chloro-3-oxo-2-(4-propan-2-ylphenyl)-4-pyridazinyl]oxy]phenyl]methyl ester | cid_46846321
Type:
Small organic molecule
Emp. Form.:
C22H21ClN2O4
Mol. Mass.:
412.866
SMILES:
CC(C)c1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(COC(C)=O)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity: