Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75965
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
2875±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75965
Synonyms:
MLS000050497 | N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-1,3-benzodioxole-5-carboxamide | N-[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-piperonylamide | SMR000076421 | cid_1294813
Type:
Small organic molecule
Emp. Form.:
C22H16N2O4
Mol. Mass.:
372.3734
SMILES:
Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)c2ccc3OCOc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: