Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75970
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
12746±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75970
Synonyms:
3-chloranyl-6-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1-benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1-benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-(5-methyl-3-isoxazolyl)-1-benzothiophene-2-carboxamide | 3-chloro-6-methyl-N-(5-methylisoxazol-3-yl)benzothiophene-2-carboxamide | MLS000535628 | SMR000143064 | cid_887251
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O2S
Mol. Mass.:
306.767
SMILES:
Cc1cc(NC(=O)c2sc3cc(C)ccc3c2Cl)no1
Structure:
Search PDB for entries with ligand similarity: