Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM41086
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
>39845±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM41086
Synonyms:
MLS000582064 | N-[3-chloranyl-4-(2-oxidanylidenechromen-3-yl)phenyl]pyridine-3-carboxamide | N-[3-chloro-4-(2-ketochromen-3-yl)phenyl]nicotinamide | N-[3-chloro-4-(2-oxo-1-benzopyran-3-yl)phenyl]-3-pyridinecarboxamide | N-[3-chloro-4-(2-oxo-2H-chromen-3-yl)phenyl]nicotinamide | N-[3-chloro-4-(2-oxochromen-3-yl)phenyl]pyridine-3-carboxamide | SMR000201281 | cid_1252084
Type:
Small organic molecule
Emp. Form.:
C21H13ClN2O3
Mol. Mass.:
376.793
SMILES:
Clc1cc(NC(=O)c2cccnc2)ccc1-c1cc2ccccc2oc1=O
Structure:
Search PDB for entries with ligand similarity: