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Target
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Ligand
BDBM75982
Substrate
n/a
Meas. Tech.
Counterscreen for NR2E3 inverse agonists
IC50
>39824±n/a nM
Citation
 PubChem, PC Counterscreen for NR2E3 inverse agonists: TR-FRET-based biochemical high throughput dose response assay to identify inverse agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) PubChem Bioassay (2010)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Synonyms:
CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (TRAC-1) | nuclear receptor corepressor 2 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81401.89
Organism:
Homo sapiens (Human)
Description:
Q9Y618-2 gi_116256445
Residue:
766
Sequence:
MAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
  
Inhibitor
Name:
BDBM75982
Synonyms:
1-(1-azepanyl)-2-[(6-thiophen-2-yl-3-pyridazinyl)thio]ethanone | 1-(azepan-1-yl)-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanyl-ethanone | 1-(azepan-1-yl)-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethanone | 1-(azepan-1-yl)-2-[[6-(2-thienyl)pyridazin-3-yl]thio]ethanone | MLS000696688 | SMR000237157 | cid_12006171
Type:
Small organic molecule
Emp. Form.:
C16H19N3OS2
Mol. Mass.:
333.472
SMILES:
O=C(CSc1ccc(nn1)-c1cccs1)N1CCCCCC1
Structure:
Search PDB for entries with ligand similarity: