Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM269508
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding Assay
pH
7.5±n/a
EC50
0.190±n/a nM
Comments
extracted
Citation
 Chen, N; Chen, X; Chen, Y; Fu, Z; Heath, JA; Horne, DB; Kaller, MR; Khakoo, AY; Kopecky, DJ; Ma, Z; Mihalic, JT; Swaminath, G; Wang, X; Yeh, W Methods of treating heart failure US Patent  US10058550 Publication Date 8/28/2018 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM269508
Synonyms:
US10058550, Example 27.0 | US10058550, Example 549.0 | US10221162, Example 38.0 | US9845310, Example 43.0 | yl)-1-methoxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H29N7O6S
Mol. Mass.:
555.606
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1 |r,wU:3.3,2.1,(6.11,-3.4,;4.62,-3,;4.22,-1.51,;2.73,-1.11,;2.33,.38,;1.64,-2.2,;.56,-3.29,;2.73,-3.29,;.56,-1.11,;-.93,-1.51,;-1.41,-2.97,;-2.95,-2.97,;-3.42,-1.51,;-4.91,-1.11,;-5.31,.38,;-6.8,.78,;-7.89,-.31,;-7.49,-1.8,;-8.58,-2.89,;-8.18,-4.38,;-6,-2.2,;-2.18,-.6,;-2.18,1.3,;-3.51,2.07,;-4.85,1.3,;-6.18,2.07,;-3.51,3.61,;-2.18,4.38,;-.84,3.61,;-.84,2.07,;.49,1.3,;1.82,2.07,;5.31,-.42,;6.8,-.82,;7.89,.27,;7.49,1.76,;8.58,2.85,;6,2.16,;4.91,1.07,)|
Structure:
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