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Target
Large T antigen
Ligand
BDBM76092
Substrate
n/a
Meas. Tech.
A confirmatory biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to quantify activity of synthesized compounds that inhibit the ATPase activity of Tag (3)
IC50
26710±n/a nM
Citation
 PubChem, PC A confirmatory biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to quantify activity of synthesized compounds that inhibit the ATPase activity of Tag (3) PubChem Bioassay (2010)[AID] 
Target
Name:
Large T antigen
Synonyms:
LT | LT-AG | LT_SV40
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81575.54
Organism:
Simian virus 40
Description:
P03070
Residue:
708
Sequence:
MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYKKMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADSQHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYSVTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDPFSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFEMCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQMLTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKRYWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGGESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWKERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHETGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET
  
Inhibitor
Name:
BDBM76092
Synonyms:
4-[1-(4-hydroxy-3-isopropyl-phenyl)-1-methyl-ethyl]-2-isopropyl-phenol | 4-[2-(4-hydroxy-3-propan-2-ylphenyl)propan-2-yl]-2-propan-2-ylphenol | 4-[2-(4-oxidanyl-3-propan-2-yl-phenyl)propan-2-yl]-2-propan-2-yl-phenol | KSC-7-289 | KUC105975N | cid_228537
Type:
Small organic molecule
Emp. Form.:
C21H28O2
Mol. Mass.:
312.4458
SMILES:
CC(C)c1cc(ccc1O)C(C)(C)c1ccc(O)c(c1)C(C)C
Structure:
Search PDB for entries with ligand similarity: