Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM270375
Substrate
n/a
Meas. Tech.
Inositol Phosphate Turnover (IP1) Assay 1
Temperature
298.15±n/a K
EC50
8233±n/a nM
Comments
extracted
Citation
 Chobanian, H; DeMong, D; Guo, Y; Hu, Z; Miller, M; Pio, B; Plummer, CW; Xiao, D; Yang, C Antidiabetic compounds US Patent  US10059667 Publication Date 8/28/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM270375
Synonyms:
US10059667, Example 96
Type:
Small organic molecule
Emp. Form.:
C23H28N2O5
Mol. Mass.:
412.4788
SMILES:
COc1ncc(OC2CC(COc3cccc(c3)[C@@H]([C@H](C)C(O)=O)C3CC3)C2)cn1 |r,wU:19.20,wD:18.18,(-10.95,-.35,;-9.61,-1.12,;-8.28,-.35,;-8.28,1.19,;-6.94,1.96,;-5.61,1.19,;-4.28,1.96,;-2.94,1.19,;-1.46,1.59,;-1.06,.1,;.28,-.67,;1.61,.1,;2.94,-.67,;2.94,-2.21,;4.28,-2.98,;5.61,-2.21,;5.61,-.67,;4.28,.1,;6.94,.1,;8.28,-.67,;8.28,-2.21,;9.61,.1,;10.95,-.67,;9.61,1.64,;6.94,1.64,;7.71,2.98,;6.17,2.98,;-2.55,-.3,;-5.61,-.35,;-6.94,-1.12,)|
Structure:
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