Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76120
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76120
Synonyms:
MLS000582175 | N-(2-methoxy-3-dibenzofuranyl)-6-methyl-2-(3-pyridinyl)-4-quinolinecarboxamide | N-(2-methoxydibenzo[b,d]furan-3-yl)-6-methyl-2-(3-pyridinyl)-4-quinolinecarboxamide | N-(2-methoxydibenzofuran-3-yl)-6-methyl-2-(3-pyridyl)cinchoninamide | N-(2-methoxydibenzofuran-3-yl)-6-methyl-2-pyridin-3-yl-quinoline-4-carboxamide | N-(2-methoxydibenzofuran-3-yl)-6-methyl-2-pyridin-3-ylquinoline-4-carboxamide | SMR000200710 | cid_2220529
Type:
Small organic molecule
Emp. Form.:
C29H21N3O3
Mol. Mass.:
459.4953
SMILES:
COc1cc2c(cc1NC(=O)c1cc(nc3ccc(C)cc13)-c1cccnc1)oc1ccccc21
Structure:
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