Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76128
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76128
Synonyms:
2-quinoxalinecarboxylic acid [3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-2-phenyl-7-isoquinolinyl] ester | CMLD004012 | MLS000438675 | SMR000452724 | [3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-bis(oxidanylidene)-2-phenyl-isoquinolin-7-yl] quinoxaline-2-carboxylate | [3-[(E)-3-methoxyprop-1-enyl]-7-methyl-6,8-dioxo-2-phenylisoquinolin-7-yl] quinoxaline-2-carboxylate | cid_16745602 | quinoxaline-2-carboxylic acid [6,8-diketo-3-[(E)-3-methoxyprop-1-enyl]-7-methyl-2-phenyl-7-isoquinolyl] ester
Type:
Small organic molecule
Emp. Form.:
C29H23N3O5
Mol. Mass.:
493.51
SMILES:
COC\C=C\C1=CC2=CC(=O)C(C)(OC(=O)c3cnc4ccccc4n3)C(=O)C2=CN1c1ccccc1 |c:31,t:5,7|
Structure:
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