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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM69393
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay
EC50
54100±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM69393
Synonyms:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chroman-4-one | 2-[3,4-bis(oxidanyl)phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one | MLS000877024 | SMR000440624 | cid_11095
Type:
Small organic molecule
Emp. Form.:
C15H12O6
Mol. Mass.:
288.2522
SMILES:
Oc1cc(O)c2C(=O)CC(Oc2c1)c1ccc(O)c(O)c1
Structure:
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