Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM50727
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM50727
Synonyms:
4-[5-[(Z)-[3-(1,1-diketothiolan-3-yl)-4-keto-2-thioxo-thiazolidin-5-ylidene]methyl]-2-furyl]benzenesulfonamide | 4-[5-[(Z)-[3-(1,1-dioxo-3-thiolanyl)-4-oxo-2-sulfanylidene-5-thiazolidinylidene]methyl]-2-furanyl]benzenesulfonamide | 4-[5-[(Z)-[3-(1,1-dioxothiolan-3-yl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzenesulfonamide | 4-[5-[(Z)-[3-[1,1-bis(oxidanylidene)thiolan-3-yl]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzenesulfonamide | 4-{5-[3-(1,1-Dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-4-oxo-2-thioxo-thiazolidin-(5Z)-ylidenemethyl]-f uran-2-yl}-benzenesulfonamide | MLS000777206 | SMR000413602 | cid_5727181
Type:
Small organic molecule
Emp. Form.:
C18H16N2O6S4
Mol. Mass.:
484.589
SMILES:
NS(=O)(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(C3CCS(=O)(=O)C3)C2=O)o1
Structure:
Search PDB for entries with ligand similarity: