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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76249
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
<195±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76249
Synonyms:
MLS002171184 | SMR001251481 | [2-[(5-nitro-1,3-thiazol-2-yl)amino]-2-oxidanylidene-ethyl] benzoate | [2-[(5-nitro-1,3-thiazol-2-yl)amino]-2-oxoethyl] benzoate | benzoic acid [2-[(5-nitro-2-thiazolyl)amino]-2-oxoethyl] ester | benzoic acid [2-keto-2-[(5-nitrothiazol-2-yl)amino]ethyl] ester | cid_5236900
Type:
Small organic molecule
Emp. Form.:
C12H9N3O5S
Mol. Mass.:
307.282
SMILES:
[O-][N+](=O)c1cnc(NC(=O)COC(=O)c2ccccc2)s1
Structure:
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