Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75703
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2
EC50
13300±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75703
Synonyms:
4-[[4-(isoxazol-3-ylcarbamoyl)-1H-imidazole-5-carbonyl]amino]piperidine-1-carboxylic acid tert-butyl ester | 4-[[[4-[(3-isoxazolylamino)-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]-1-piperidinecarboxylic acid tert-butyl ester | MLS002206716 | SMR001306546 | cid_42628369 | tert-butyl 4-[[4-(1,2-oxazol-3-ylcarbamoyl)-1H-imidazol-5-yl]carbonylamino]piperidine-1-carboxylate | tert-butyl 4-[[4-(1,2-oxazol-3-ylcarbamoyl)-1H-imidazole-5-carbonyl]amino]piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H24N6O5
Mol. Mass.:
404.4204
SMILES:
CC(C)(C)OC(=O)N1CCC(CC1)NC(=O)c1nc[nH]c1C(=O)Nc1ccon1
Structure:
Search PDB for entries with ligand similarity: