Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM71596
Substrate
n/a
Meas. Tech.
SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3
IC50
>32000±n/a nM
Citation
 PubChem, PC SAR Analysis of Antagonists of the DOR Receptor using an Image-Based Assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM71596
Synonyms:
2-(7-fluoranyl-4-oxidanylidene-pyrrolo[1,2-a]quinoxalin-5-yl)-N-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]ethanamide | 2-(7-fluoro-4-keto-pyrrolo[1,2-a]quinoxalin-5-yl)-N-[3-[4-(4-fluorophenyl)piperazino]propyl]acetamide | 2-(7-fluoro-4-oxo-5-pyrrolo[1,2-a]quinoxalinyl)-N-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]acetamide | 2-(7-fluoro-4-oxopyrrolo[1,2-a]quinoxalin-5-yl)-N-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]acetamide | KSC-1-178 | KUC104209N | cid_22522715
Type:
Small organic molecule
Emp. Form.:
C26H27F2N5O2
Mol. Mass.:
479.5217
SMILES:
Fc1ccc(cc1)N1CCN(CCCNC(=O)Cn2c3cc(F)ccc3n3cccc3c2=O)CC1
Structure:
Search PDB for entries with ligand similarity: