Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76317
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76317
Synonyms:
2-(4,5-dihydrobenzo[g][1]benzothiol-2-yl)-5-(methylthio)-1,3,4-oxadiazole | 2-(4,5-dihydrobenzo[g][1]benzothiol-2-yl)-5-methylsulfanyl-1,3,4-oxadiazole | 2-(4,5-dihydrobenzo[g]benzothiophen-2-yl)-5-(methylthio)-1,3,4-oxadiazole | 2-(4,5-dihydronaphtho[1,2-b]thiophen-2-yl)-5-(methylsulfanyl)-1,3,4-oxadiazole | MLS000326827 | SMR000179408 | cid_4351721
Type:
Small organic molecule
Emp. Form.:
C15H12N2OS2
Mol. Mass.:
300.399
SMILES:
CSc1nnc(o1)-c1cc2CCc3ccccc3-c2s1
Structure:
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