Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM76195
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM76195
Synonyms:
6-Oxo-6H-pyran-3-carboxylic acid N'-(2-bromo-1-methyl-cyclopropanecarbonyl)-hydrazide | MLS000768335 | N'-(2-bromanyl-1-methyl-cyclopropyl)carbonyl-6-oxidanylidene-pyran-3-carbohydrazide | N'-(2-bromo-1-methyl-cyclopropanecarbonyl)-6-keto-pyran-3-carbohydrazide | N'-(2-bromo-1-methylcyclopropanecarbonyl)-6-oxopyran-3-carbohydrazide | N'-[(2-bromo-1-methylcyclopropyl)-oxomethyl]-6-oxo-3-pyrancarbohydrazide | SMR000431656 | cid_3510920
Type:
Small organic molecule
Emp. Form.:
C11H11BrN2O4
Mol. Mass.:
315.12
SMILES:
CC1(CC1Br)C(=O)NNC(=O)c1ccc(=O)oc1
Structure:
Search PDB for entries with ligand similarity: