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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM75655
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
EC50
52600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM75655
Synonyms:
1-[[1-(2-methylbenzyl)-4-piperidyl]methyl]-3-(3,4,5-trimethoxyphenyl)urea | 1-[[1-[(2-methylphenyl)methyl]-4-piperidinyl]methyl]-3-(3,4,5-trimethoxyphenyl)urea | 1-[[1-[(2-methylphenyl)methyl]piperidin-4-yl]methyl]-3-(3,4,5-trimethoxyphenyl)urea | MLS001200276 | N-{[1-(2-methylbenzyl)piperidin-4-yl]methyl}-N'-(3,4,5-trimethoxyphenyl)urea | SMR000563484 | cid_23609225
Type:
Small organic molecule
Emp. Form.:
C24H33N3O4
Mol. Mass.:
427.5365
SMILES:
COc1cc(NC(=O)NCC2CCN(Cc3ccccc3C)CC2)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: