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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM63469
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
15400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM63469
Synonyms:
1-[(1-ethyl-2-methyl-benzimidazol-5-yl)carbonylamino]-3-phenyl-thiourea | 1-[(1-ethyl-2-methyl-benzimidazole-5-carbonyl)amino]-3-phenyl-thiourea | 1-[(1-ethyl-2-methylbenzimidazole-5-carbonyl)amino]-3-phenylthiourea | 1-[[(1-ethyl-2-methyl-5-benzimidazolyl)-oxomethyl]amino]-3-phenylthiourea | MLS000391824 | SMR000260858 | cid_2324822
Type:
Small organic molecule
Emp. Form.:
C18H19N5OS
Mol. Mass.:
353.441
SMILES:
CCn1c(C)nc2cc(ccc12)C(=O)NNC(=S)Nc1ccccc1
Structure:
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