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Target
Caspase-3
Ligand
BDBM76433
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
4220±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76433
Synonyms:
2-[3-(6-Methyl-1H-benzoimidazol-2-yl)-pyridin-2-ylsulfanyl]-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone | 2-[3-(6-methyl-1H-benzimidazol-2-yl)pyridin-2-yl]sulfanyl-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone | 2-[[3-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone | 2-[[3-(6-methyl-1H-benzimidazol-2-yl)-2-pyridyl]thio]-1-(2-methylindolin-1-yl)ethanone | MLS000557795 | SMR000173693 | cid_3231085
Type:
Small organic molecule
Emp. Form.:
C24H22N4OS
Mol. Mass.:
414.523
SMILES:
CC1Cc2ccccc2N1C(=O)CSc1ncccc1-c1nc2ccc(C)cc2[nH]1
Structure:
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