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Target
Caspase-3
Ligand
BDBM76493
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
2710±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76493
Synonyms:
2,5-dimethyl-N-[(Z)-(1-methyl-2-oxidanylidene-indol-3-ylidene)amino]furan-3-carboxamide | 2,5-dimethyl-N-[(Z)-(1-methyl-2-oxo-3-indolylidene)amino]-3-furancarboxamide | 2,5-dimethyl-N-[(Z)-(1-methyl-2-oxoindol-3-ylidene)amino]furan-3-carboxamide | MLS000394970 | N-[(Z)-(2-keto-1-methyl-indolin-3-ylidene)amino]-2,5-dimethyl-3-furamide | SMR000248462 | cid_5790282
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3
Mol. Mass.:
297.3086
SMILES:
CN1C(=O)\C(=N/NC(=O)c2cc(C)oc2C)c2ccccc12
Structure:
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