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Target
Caspase-3
Ligand
BDBM76682
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
67500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76682
Synonyms:
(5E)-3-benzyl-5-(3,4-dihydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one | (5E)-3-benzyl-5-(3,4-dihydroxybenzylidene)-2-thioxo-thiazolidin-4-one | (5E)-3-benzyl-5-[(3,4-dihydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-5-[(3,4-dihydroxyphenyl)methylidene]-3-(phenylmethyl)-2-sulfanylidene-4-thiazolidinone | (5E)-5-[[3,4-bis(oxidanyl)phenyl]methylidene]-3-(phenylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one | MLS001194433 | SMR000555226 | cid_2054727
Type:
Small organic molecule
Emp. Form.:
C17H13NO3S2
Mol. Mass.:
343.42
SMILES:
Oc1ccc(\C=C2\SC(=S)N(Cc3ccccc3)C2=O)cc1O
Structure:
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