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Target
Caspase-3
Ligand
BDBM76710
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
3790±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76710
Synonyms:
4-chloranyl-N-(2-methyl-1,3-benzothiazol-6-yl)pyridine-2-carboxamide | 4-chloro-N-(2-methyl-1,3-benzothiazol-6-yl)-2-pyridinecarboxamide | 4-chloro-N-(2-methyl-1,3-benzothiazol-6-yl)picolinamide | 4-chloro-N-(2-methyl-1,3-benzothiazol-6-yl)pyridine-2-carboxamide | MLS001175325 | SMR000592544 | cid_7598302
Type:
Small organic molecule
Emp. Form.:
C14H10ClN3OS
Mol. Mass.:
303.767
SMILES:
Cc1nc2ccc(NC(=O)c3cc(Cl)ccn3)cc2s1
Structure:
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