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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM76177
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
IC50
23900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM76177
Synonyms:
1-(5-chloranyl-2-methoxy-phenyl)-3-(3,3-diphenylpropyl)thiourea | 1-(5-chloro-2-methoxy-phenyl)-3-(3,3-diphenylpropyl)thiourea | 1-(5-chloro-2-methoxyphenyl)-3-(3,3-diphenylpropyl)thiourea | MLS000581257 | N-(5-chloro-2-methoxyphenyl)-N'-(3,3-diphenylpropyl)thiourea | SMR000199871 | cid_2029536
Type:
Small organic molecule
Emp. Form.:
C23H23ClN2OS
Mol. Mass.:
410.96
SMILES:
COc1ccc(Cl)cc1NC(=S)NCCC(c1ccccc1)c1ccccc1
Structure:
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