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Target
Caspase-3
Ligand
BDBM77499
Substrate
n/a
Meas. Tech.
Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3
EC50
3540±n/a nM
Citation
 PubChem, PC Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3 PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM77499
Synonyms:
2-(2-Methoxy-phenylamino)-8-methyl-quinoline-3-carbonitrile | 2-(2-methoxyanilino)-8-methyl-3-quinolinecarbonitrile | 2-(2-methoxyanilino)-8-methylquinoline-3-carbonitrile | 2-[(2-methoxyphenyl)amino]-8-methyl-quinoline-3-carbonitrile | 8-methyl-2-(o-anisidino)quinoline-3-carbonitrile | MLS000551998 | SMR000172503 | cid_865262
Type:
Small organic molecule
Emp. Form.:
C18H15N3O
Mol. Mass.:
289.3312
SMILES:
COc1ccccc1Nc1nc2c(C)cccc2cc1C#N
Structure:
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