Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 4
Ligand
BDBM77618
Substrate
n/a
Meas. Tech.
SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology
IC50
3140±n/a nM
Citation
 PubChem, PC SAR Analysis for the identification of selective inhibits of the transient receptor potential cation channel C4 (TRPC4): Automated Electrophysiology PubChem Bioassay (2010)[AID] 
Target
Name:
Short transient receptor potential channel 4
Synonyms:
TRPC4_MOUSE | Trpc4 | Trrp4 | alternatively spliced Trp4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
111587.67
Organism:
Mus musculus
Description:
Q9QUQ5
Residue:
974
Sequence:
MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNSLIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKMRRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGSKLSTIQSANAASSADSDEKSQSEGNGKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQCVLVDHRERNTDTLGLQVGKRVCSTFKSEKVVVEDTVPIIPKEKHAHEEDSSIDYDLSPTDTAAHEDYVTTRL
  
Inhibitor
Name:
BDBM77618
Synonyms:
4-methyl-2-(4-methyl-1-piperidinyl)quinoline;2,2,2-trifluoroacetic acid | 4-methyl-2-(4-methylpiperidin-1-yl)quinoline;2,2,2-trifluoroacetic acid | 4-methyl-2-(4-methylpiperidin-1-yl)quinoline;2,2,2-tris(fluoranyl)ethanoic acid | 4-methyl-2-(4-methylpiperidino)quinoline;2,2,2-trifluoroacetic acid | VU0418904-1 | cid_46259330
Type:
Small organic molecule
Emp. Form.:
C16H20N2
Mol. Mass.:
240.3434
SMILES:
CC1CCN(CC1)c1cc(C)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: