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Target
Mineralocorticoid receptor [729-984]
Ligand
BDBM238163
Substrate
n/a
Meas. Tech.
scintillation proximity assay (SPA)
IC50
82.0±n/a nM
Citation
 O Mahony, G; Kossenjans, M; Edman, K; Kajanus, J; Hogner, CA; Cornwall, P; Turner, A Benzoxazinone amides as mineralocorticoid receptor modulators US Patent  US10017502 Publication Date 7/10/2018 
Target
Name:
Mineralocorticoid receptor [729-984]
Synonyms:
MCR | MCR_HUMAN | MLR | Mineralocorticoid receptor (MR) | Mineralocorticoid receptor(MR)( (T729-K985) | NR3C2
Type:
Enzyme
Mol. Mass.:
29747.25
Organism:
Homo sapiens (Human)
Description:
amino acids T729-K985
Residue:
256
Sequence:
TISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
  
Inhibitor
Name:
BDBM238163
Synonyms:
US10017502, Example 6 | US9394291, 6 | US9394291, 6a | US9394291, 6b
Type:
Small organic molecule
Emp. Form.:
C20H18ClN3O5
Mol. Mass.:
415.827
SMILES:
CNC(=O)CC1COc2cc(Cl)ccc2N1C(=O)c1ccc2OCC(=O)Nc2c1
Structure:
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