Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM55880
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
3496±109 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM55880
Synonyms:
(E)-N-(4-amino-2-methyl-6-quinolinyl)-3-(2-chlorophenyl)-2-propenamide | (E)-N-(4-amino-2-methyl-6-quinolyl)-3-(2-chlorophenyl)acrylamide | (E)-N-(4-amino-2-methylquinolin-6-yl)-3-(2-chlorophenyl)prop-2-enamide | (E)-N-(4-azanyl-2-methyl-quinolin-6-yl)-3-(2-chlorophenyl)prop-2-enamide | MLS000737665 | SMR000393832 | cid_5773323
Type:
Small organic molecule
Emp. Form.:
C19H16ClN3O
Mol. Mass.:
337.803
SMILES:
Cc1cc(N)c2cc(NC(=O)\C=C\c3ccccc3Cl)ccc2n1
Structure:
Search PDB for entries with ligand similarity: