Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78967
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
>20000±0 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78967
Synonyms:
1-tert-butyl-6-methyl-3-(1-naphthalenylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine | 1-tert-butyl-6-methyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1-tert-butyl-6-methyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine | MLS001065853 | SMR000486342 | [1-tert-butyl-6-methyl-3-(1-naphthylmethyl)pyrazolo[3,4-d]pyrimidin-4-yl]amine | cid_24747149
Type:
Small organic molecule
Emp. Form.:
C21H23N5
Mol. Mass.:
345.4408
SMILES:
Cc1nc(N)c2c(Cc3cccc4ccccc34)nn(c2n1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: