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Target
Perilipin-1
Ligand
BDBM48899
Substrate
n/a
Meas. Tech.
Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain
IC50
21420±n/a nM
Citation
 PubChem, PC Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) PubChem Bioassay (2011)[AID] 
Target
Name:
Perilipin-1
Synonyms:
PERI | PLIN | PLIN1 | PLIN1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55988.69
Organism:
Homo sapiens (Human)
Description:
gi_223718203
Residue:
522
Sequence:
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS
  
Inhibitor
Name:
BDBM48899
Synonyms:
(E)-2-(2,3-Dihydro-indole-1-carbonyl)-3-(4-hydroxy-3-methoxy-phenyl)-acrylonitrile | (E)-2-(2,3-dihydroindol-1-ylcarbonyl)-3-(3-methoxy-4-oxidanyl-phenyl)prop-2-enenitrile | (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enenitrile | (E)-2-[2,3-dihydroindol-1-yl(oxo)methyl]-3-(4-hydroxy-3-methoxyphenyl)-2-propenenitrile | (E)-3-(4-hydroxy-3-methoxy-phenyl)-2-(indoline-1-carbonyl)acrylonitrile | MLS000779135 | SMR000415839 | cid_1975835
Type:
Small organic molecule
Emp. Form.:
C19H16N2O3
Mol. Mass.:
320.3419
SMILES:
COc1cc(\C=C(/C#N)C(=O)N2CCc3ccccc23)ccc1O
Structure:
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