Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM64759
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical dose response competitive binding lanthascreen assay for partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg)
IC50
14000±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical dose response competitive binding lanthascreen assay for partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg) PubChem Bioassay (2011)[AID] 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM64759
Synonyms:
3-(furan-2-carbonyl)-4-hydroxy-1-(6-methyl-1,3-benzothiazol-2-yl)-2-(5-methylfuran-2-yl)-2H-pyrrol-5-one;oxalic acid | 3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(6-methyl-1,3-benzothiazol-2-yl)-2-(5-methyl-2-furanyl)-2H-pyrrol-5-one;oxalic acid | 4-(2-furoyl)-3-hydroxy-1-(6-methyl-1,3-benzothiazol-2-yl)-5-(5-methyl-2-furyl)-3-pyrrolin-2-one;oxalic acid | 4-(Furan-2-carbonyl)-3-hydroxy-1-(6-methyl-benzothiazol-2-yl)-5-(5-methyl-furan-2-yl)-1,5-dihydro-pyrrol-2-one | MLS001221390 | SMR000612215 | cid_24792442 | ethanedioic acid;3-(furan-2-ylcarbonyl)-1-(6-methyl-1,3-benzothiazol-2-yl)-2-(5-methylfuran-2-yl)-4-oxidanyl-2H-pyrrol-5-one
Type:
Small organic molecule
Emp. Form.:
C22H16N2O5S
Mol. Mass.:
420.438
SMILES:
Cc1ccc(o1)C1C(C(=O)c2ccco2)C(=O)C(=O)N1c1nc2ccc(C)cc2s1
Structure:
Search PDB for entries with ligand similarity: