Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM404313
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
26.8±n/a nM
Citation
 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N; Yu, T Piperidine isoxazole and isothiazole orexin receptor antagonists US Patent  US10017504 Publication Date 7/10/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM404313
Synonyms:
1-(2-{[(2R,5R)-2-Methyl-5-{3-[(1R)- 2,2,2-Trifluoro-1-hydroxyethyl]isoxazol- 5-yl}piperidin-1- yl]carbonyl}phenyl) cyclopropanecarbonitrile | US10017504, 44
Type:
Small organic molecule
Emp. Form.:
C22H22F3N3O3
Mol. Mass.:
433.4236
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1cc(no1)[C@@H](O)C(F)(F)F
Structure:
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