Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77965
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
8710±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77965
Synonyms:
2-(3-hydroxypropylamino)-3-methyl-4-spiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]one | 2-(3-hydroxypropylamino)-3-methyl-spiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one | 2-(3-hydroxypropylamino)-3-methylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one | 3-methyl-2-(3-oxidanylpropylamino)spiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one | MLS000029341 | SMR000009432 | cid_650809
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
Cn1c(NCCCO)nc2-c3ccccc3CC3(CCCCC3)c2c1=O
Structure:
Search PDB for entries with ligand similarity: