Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM77992
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
28400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM77992
Synonyms:
1-phenyl-N-(3-pyridinyl)-3-thiophen-2-yl-4-pyrazolecarboxamide | 1-phenyl-N-(3-pyridyl)-3-(2-thienyl)pyrazole-4-carboxamide | 1-phenyl-N-pyridin-3-yl-3-thiophen-2-yl-pyrazole-4-carboxamide | 1-phenyl-N-pyridin-3-yl-3-thiophen-2-ylpyrazole-4-carboxamide | MLS000081870 | SMR000060432 | cid_2999058
Type:
Small organic molecule
Emp. Form.:
C19H14N4OS
Mol. Mass.:
346.406
SMILES:
O=C(Nc1cccnc1)c1cn(nc1-c1cccs1)-c1ccccc1
Structure:
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