Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78000
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
3340±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78000
Synonyms:
MLS000091924 | N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-7-methoxy-2-furo[2,3-b]quinolinecarboxamide | N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-7-methoxy-furo[2,3-b]quinoline-2-carboxamide | N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)ethyl]-7-methoxyfuro[2,3-b]quinoline-2-carboxamide | N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl]-7-methoxyfuro[2,3-b]quinoline-2-carboxamide | SMR000026448 | cid_3238061
Type:
Small organic molecule
Emp. Form.:
C24H23N3O3
Mol. Mass.:
401.4577
SMILES:
COc1ccc2cc3cc(oc3nc2c1)C(=O)NCCN1CCc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: