Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM73857
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
41900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM73857
Synonyms:
2-(4-nitrophenyl)propanoic acid [[amino-(4-methylphenyl)methylidene]amino] ester | 2-(4-nitrophenyl)propionic acid [[amino(p-tolyl)methylene]amino] ester | MLS001181255 | SMR000502388 | [[amino-(4-methylphenyl)methylidene]amino] 2-(4-nitrophenyl)propanoate | [[azanyl-(4-methylphenyl)methylidene]amino] 2-(4-nitrophenyl)propanoate | cid_2943294
Type:
Small organic molecule
Emp. Form.:
C17H17N3O4
Mol. Mass.:
327.3346
SMILES:
CC(C(=O)O[N-]C(=[NH2+])c1ccc(C)cc1)c1ccc(cc1)[N+]([O-])=O
Structure:
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